Remote control of apomorphine infusion rate in Parkinson's disease: Real-time dose variations according to the patients' motor state. A proof of concept.
نویسندگان
چکیده
1 Clinical Research Unit, Fundación Sant Antoni Abat (Consorci Sanitiari del Garraf), Barcelona, Spain 2 School of Engineering and Informatics, National University of Ireland at Galway, Galway, Ireland. 3 Department of Neurology, Hospital Universitario Infanta Cristina, Parla-Madrid, Spain. 4 Department of Neurology, Hospital Universitari Vall d'Hebron, Barcelona, Spain. 5 Department of Neurology, Hospital Universitario Ramón y Cajal, Madrid, Spain. 6 Department of Neurology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain. 7 Technical Research Centre for Dependency Care and Autonomous Living, Universitat Politècnica de Catalunya, Barcelona, Spain 8 Maccabi Institute for Health Services Research, Tel-Aviv, Israel. * Author deceased.
منابع مشابه
Rate and severity of depression in patients with Parkinson's disease
Depression is common and may occur at any stage in the long history of Parkinson’s disease, markedly affecting a patient’s threshold to discomfort, but it is particularly difficult to assess before clear clinical features are evident. The rate of depression in patients with Parkinson’s disease vary, partly because of differences in the definition of depression, difficulties in distinguishing be...
متن کاملRate and severity of depression in patients with Parkinson's disease
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Background and Objective: Parkinson's disease is a rather common movement disorder in aged individuals due to degeneration of dopaminergic neurons within the substantia nigra pars compacta. Due to antioxidant, anti-inflammatory and protective effects of the flavanone hesperetin, the present study assessed dose-dependent effect of hesperetin on motor asymmetry induced by intrastriatal injection ...
متن کاملMovement Disorders Parkinson’s Disease
Apomorphine administered subcutaneously has provided clinicians with an effective option for the rapid resolution of the symptoms of Parkinson’s disease (PD) for over a quarter of a century. It is available for use either as an intermittent injection or a continuous infusion, depending on the severity of the patient’s symptoms. This satellite symposium, held during the 18th International Congre...
متن کاملSubcutaneous apomorphine in late stage Parkinson's disease: a long term follow up.
OBJECTIVES Despite the recent introduction of new peroral drugs as well as neurosurgical methods for Parkinson's disease, treatment of late stage parkinsonian patients remains difficult and many patients become severely handicapped because of fluctuations in their motor status. Injections and infusions of apomorphine has been suggested as an alternative in the treatment of these patients, but t...
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عنوان ژورنال:
- Parkinsonism & related disorders
دوره 21 8 شماره
صفحات -
تاریخ انتشار 2015